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Early stage screening of Alzheimer's disease by detecting subtypes of MCI...with a normal webcam POC.

A reliable and inexpensive diagnostic test that can be used in any doctor's office all over the world....

AI 4.0...A decision making tool for GP's ( General Practitioner ) Nature.com

New treatment (cure) for Alzheimer's disease : We are looking for investors 200 K for a POC ( proof of concept) based on Metatranscriptomics and AI, ML and DL.    email:click here


THERE IS A BIG DIFFERENCE BETWEEN A BIOMARKER FOR ALZHEIMER'S DISEASE AND A DIGITAL BIOMARKER...

Biomarker for Alzeimer's: can be a toxic protein like amyloid or TAU

Digital biomarker: can give you data about the function of different parts of your brain

Only with digital biomarkers you can make a differentation between Alzheimer's disease and other neurodegenerative diseases preclinical...like Lewy Body dementia with 80% misdiagnosis and 50% get a diagnosis of Alzheimer's disease

 The reason why 99,6% of all Alzheimer's drugs fail...even with neurons without any plaques...we still have an old neuron with low neuroplasticity and low communication...New neurons Archive Old memories...



ALZHEIMER's IS ASSOCIATED WITH A SYNAPTIC DYSFUNCTION RATHER THAN THE DISAPPEARANCE OR SYNAPTIC DESTRUCTION...this change therapeutic approach...http://www.douglas.qc.ca

A new study reveals older adults can generate just as many new hippocampal neurons from progentior cells as young people. The findings confirm neurogenesis does occur in older individuals. Cell Press.April 2018


Detecting Alzheimer's disease before it's too late...




Big data is the fundamental building block of machine learning

Big data, is, essentially, exactly what it's called: a ton of data. Algorithms sort through this vast collection of information so that technology can predict what we'll do next.Machine learning is all about sorting through those troves of collected information to discern patterns and predict new ones   






 According to researchers, adult born neurons play a critical role in the identification of sensory stimulus and the positive values associated with sensory experience. Institute Pasteur


Although we have known for several years that the adult brain can produce new neurons, many questions about the properties conferred by these adult-born neurons were left unanswered. What advantages could they offer that could not be offered by the neurons generated shortly after birth...

Scientists from the Institut Pasteur and the CNRS have demonstrated that the new neurons produced in adults react preferentially to reward-related sensory stimuli and help speed up the association between sensory information and reward. Adult-born neurons therefore play an important role in both the identification of a sensory stimulus and the positive value associated with that sensory experience. The neurons generated shortly after birth are unable to perform this function.


These findings are published in the journal PNAS on February 19, 2018.


The future of medicine is based in data and analytics


The goal isn’t to replace physicians or healthcare professionals, but give them better decision-making tools

DL is an algorithmic technique modeled after the neural structures in human brains. The term is sometimes referred to as “neural networks” because researchers were inspired by the synapses and neurons in the human brain and the mechanism by which neurons fire and cause synapses to collect and propagate the energy of that neuron.

Treatment of Alzheimer's disease


Curcumin improves memory and mood, new UCLA study says...American Journal of Geriatric Psychiatry 22 Jan. 2018


The double-blind, placebo-controlled study involved 40 adults between the ages of 50 and 90 years who had mild memory complaints. Participants were randomly assigned to receive either a placebo or 90 milligrams of curcumin twice daily for 18 months.“These results suggest that taking this relatively safe form of curcumin could provide meaningful cognitive benefits over the years,” said Small, UCLA’s Parlow–Solomon Professor on Aging..

Bioavailability is very important...Curcumin Plus  27 X available Feb/ March 2018 for Europe...

                                                                                                            Curcumin market 2016-2024

              

I

PET amyloid = hospital

Too late

Not available in all places

High cost

Expert reader training

RADIATION EXPOSURE

Monitoring not possible

EYE TRACKING

Not invasive = NO PAIN

No radiation exposure

Lumbar punction

spinal fluid

Collection invasive

Lab to lab variability

Full alignment of standarization of technique for CFS collection not obtained

NO standardization of assay

Accurate diagnosis is needed for Dementia Lewy Body

Dementia with Lewy Bodies (DLB) may account for up to 30% of all dementia cases. The symptoms of DBL can be difficult to disentangle from other dementia subtypes. DLB is characterized by a build-up of abnormal proteins (Lewy bodies) in areas that control cognition, movement, allertness and behavior.

Eye tracking ( saccadic eye movement tracking) and EEG are very sensitive digital biomarkers to make an accurate diagnosis.

AD and DLB pathologies often overlap within individuals. An individual is diagnosed with Parkinson disease dementia ( PDD) or DLB depends on the timing of symptoms onset. In dementia with Lewy Bodies, cognitive decline occurs within one year of the onset of movement disorder symptoms.

DLB is sensivity to antipsychotic drugs. We see also REM behavior disorder. Visual hallucinations and fluctuations in cognition, attention and allertness.

                                                                            

 Mild Cognitive Impairment or MCI

MCI causes a slight but noticeable and measurable decline in cognitive abilities, including memory and thinking skills. Long-term studies suggest that 15-20 percent of the aged 65 and older may have MCI. There is a difference between normal aging cognitive decline and MCI. With all kind of rating scales it is not possible to see any difference.

Biomarkers for Alzheimer's disease can be really measured to indicate the presence or absense of the disease. For AD there is only one biomarker accepted amyloid beta. Preclinical b. amyloid as biomarker is difficult and very expensive to detect and it is only possible in hospitals. Digital biomarkers can be used outside the hospital POC ( in the waiting room or at home).

Blood glucose levels are a biomarker for diabetes and blood cholesterol for heart disease.











Guy Bisschops

guy@neuroteg.com

T: +32 11 397523

M: 0497 21 93 40




Neuroteg AI

Centrum Zuid 1111

3530 Houthalen-Helchteren

Belgium

Tel: +32 11 397523

Mob: 0497 219340


info@neuroteg.com


These are the most commonly misdiagnosed conditions.


Parkinson’s disease


It is a degenerative disorder of the central nervous system with symptoms including tremors in hands, arms or legs, stiff muscles, and problems with balance or walking.


However, it is commonly mistaken for Alzheimer’s disease, stroke, stress, a traumatic head injury and essential tremor.


Grave’s disease


The condition causes an overactive thyroid gland, and is the most common cause of hyperthyroidism.


Symptoms include eyes bulging, anxiety, sweating, rapid pulse, unplanned weight loss or gain, and extreme tiredness.


Without treatment, it can prove life-threatening, however it is often mistaken for depression, ageing and under-exercising.

Fibromyalgia


It is a chronic arthritis-like disorder characterised by widespread pain.


However, symptoms - anxiety, sensitivity to pain and incapacitating fatigue - can be confused with rheumatoid arthritis and chronic fatigue syndrome.


Normal pressure hydrocephalus


It is a build-up of cerebrospinal fluid in the brain that most commonly occurs after a stroke or ahead injury from a fall.


Symptoms of unsteady gait, progressive dementia and urinary problems, can be interpreted as Alzheimer’s disease or Parkinson’s disease.


Multiple Sclerosis


The progressive autoimmune disease that attacks the central nervous system has symptoms including muscle spasms, lack of coordination, balance problems, blurred vision and cognitive impairment.


However, it is commonly mistaken for a viral infection, lupus, Alzheimer’s disease and bipolar disorder.


Coeliac disease


It is an autoimmune disorder marked by an inability to digest gluten, a protein in wheat, rye and barley.


Symptoms can include vomiting, abdominal pain and bloating, diarrhoea, weight loss, anaemia and leg cramps.


However it can be mistaken for irritable bowel syndrome, Crohn’s disease and cystic fibrosis

Chronic fatigue syndrome


The complex disorder has no known cause but symptoms include loss of memory or concentration, a sore throat, painful lymph nodes in neck or armpits, unexplained muscle or joint pain and extreme exhaustion.


It is often confused with sinus problems, hepatitis, fibromyalgia, lupus and rheumatoid arthritis.


Lupus


It is a chronic inflammatory disease, with symptoms including fatigue, kidney, heart and lung damage, rash and joint pain.


However, it can be mistaken for chronic fatigue syndrome, fibromyalgia and rheumatoid arthritis.


Aortic dissection


This is where a tear develops in the aorta, the largest blood vessel branching from the heart, which causes the inner and middle layers to separate.


Symptoms can include sudden chest or upper back pain, loss of consciousness, shortness of breath, sweating and weak pulse in one arm.


However it can be misdiagnosed as heartburn, heart attack and stroke.