Metaverse for Alzheimer's disease with digital twins...
It is better to integrate medicines into technology than develop technology for medicines...
Why Metaverse for neurodegenerative diseases like Alzheimer's disease?
Our brain is a computational machine
For the past 100 years, neuroscientists have approached the brain like map-makers. Which areas use the mental function? We have an area for rationality ( prefrontal cortex), for coordinates movements ( motor cortex), our perception of the physical world ( somatosensory cortex), memories- language- emotions (temporal lobes), visual information (occipital lobe) and motor commands ( cerebellum). Recent studies of traditional categories of cognitive brain functions surprising amount of activities that overlap different parts of the brain so that the simple map lose their meaning. With a computational approach, we see all kinds of activities for which we don't get have names. Traditional medicines shall work on a specific area of the brain through neuroreceptors but that's only a small part of a specific function. With the Metaverse, we train and stimulate the whole function not only a small part of it. Medicines are necessary to make a quicker progression..
We have very positive informal (not-controlled) case studies for dementia and severe stroke with poor recovery prognosis.
Alzheimer's digital twins
We use digital twins for Alzheimer's disease for early diagnosis, monitoring or tracking, medical devices, personalizing drugs. In our brain digital twin we have different digital twins, prefrontal digital twin, somatosensory DT, temporal lobes DT, occipital lobe DT, cerebellum DT. Everything created in the metaverse nears the status of its physical turn including the interactions and realities between everything else. In the metaverse we have the patient medical history (including genomic data), current condition, and future needs. Patients can have their treatment at the right time, in the right way with the best possible outcomes. From personalized diagnosis and therapy selection to procedure planning and guidance...How shall the patient react on a therapy, medicine or intervention? We can predict future outcomes when a medicine shall be necessary to take....predict what happen if we don't take that medicine or therapy...we can make a SIMULATION enable to take copies of the digital twins. Copy digital twin input into the physical environment. We can INTERACT with this replica and feel the experience with mixed reality. All medical data from the patient create a specific biophysical model including a virtual version of our brain which looks behaves and reacts just like the real one through a seamless flow of data and advanced analytics capabilities a Dr. can comet the patient digital twin with intelligence on similar cases and select oblation as the therapy with the best possible predicted outcomes both in the short and long run.
- 7,9 Trillion is the potential cost savings for the current US population from early diagnosis of AD
- 1 patient: estimated lifetime cost $341,840
- 18,4 billion hours of care value or 232 billion are provided by family and friends unpaid
- 1 in 3 seniors dies with AD or another dementia
75% dementia not diagnosed or 41 million
25% have a diagnosis of which 20% misdiagnosed
This is only the tip of the iceberg
The use of VR and AR in psychotherapy and reminisence therapy can help to maintain health and well-being in older adults. The tools can contribute to maintaining older adults motor abilities, fitness, cognition, balance and memory...
VR intervention programs can be used to train cognitive and fysical functions in older adults with mild cognitive impairments...
Gao et al., 2020
Corregidor-Sanchez et al
2023 Shortage: 50.000 psychiatrists, 78.000 mental health counselors, 171.000 psychologists, 500.000 GPs, 50 M caregivers... WHO: "The world needs 6 M nurses by 2020 ... "
Why a social AI-robot need Human Interface....?
1. Co-presence...this is the effect of sharing the same experience with someone because you share the same place. Because co-presence make us believe that we share or have a simular experience.
2. Physical proximity...this is the study of physical distance and formation.Sitting one meter from someone is very different from sitting five meters away.
3.Behavioral Realism...this is the complete absence or presence of nonverbal behavioral...predictor of perceived social presence...
Computerised cognitive behavioural therapy ( CBT)
The ability to provide CBT to a larger population is not possible using traditional methods. CBT for Alzheimer's and dementia treatment, as a fully automated, advanced algorithm-driven program being used without any support from a human, offers a sollution to the problem of scalability.
CBT is practiculary appropriate for digitisation, given its structured format, emphasis an active participation and self-monitoring and intrasession "homeworks" requirements. Computerised CBT for Alzheimer's disease has been shown to be an effective treatment with effects comparable to those found for face-to-face therapy.
AI chatbot for dementia and Alzheimer's patients
The robots that caregivers want
Un. of California San Diego
Study Alzheimer's and Dementia robots
- pet-like robots
- cleaning robots
- telepresence robots
- smart speakers
1. Robots to be capable of facial recognition
2. Support positive moments shared by caregivers and their loved ones
3. Lessen caregivers emotional stress by taking on difficult tasks...such as answering repeated questions and restricting healthy food
4.Robots should be able to adopt to new situations ( progression of the disease)
5. Robots should be able to learn from end users and customize and personalize
6. Human-l with ike components not look like humans
7. Interact with human via voice activation
^Personality of our robots are based on the OCEAN personality theory
In 2011, a researcher did a postmortem analysis of 426 Japanese-American residents of Hawaii, about half of whom had been diagnosed with some form of dementia, typically Alzheimer’s. According to the autopsies, roughly half of that group had been misdiagnosed as having Alzheimer’s — their brains didn’t show evidence of the brain lesions typical of the disease. At a 2016 conference, Canadian scientists presented preliminary findings, based on more than 1,000 individuals, that patients were correctly diagnosed only 78 percent of the time. In nearly 11 percent of cases, patients thought to have Alzheimer’s actually didn’t, while another 11 percent did have the disease but weren’t diagnosed.
Accurate diagnosis is needed for Dementia Lewy Body
Dementia with Lewy Bodies (DLB) may account for up to 30% of all dementia cases. The symptoms of DBL can be difficult to disentangle from other dementia subtypes. DLB is characterized by a build-up of abnormal proteins (Lewy bodies) in areas that control cognition, movement, allertness and behavior.
Eye tracking ( saccadic eye movement tracking) and EEG are very sensitive digital biomarkers to make an accurate diagnosis.
AD and DLB pathologies often overlap within individuals. An individual is diagnosed with Parkinson disease dementia ( PDD) or DLB depends on the timing of symptoms onset. In dementia with Lewy Bodies, cognitive decline occurs within one year of the onset of movement disorder symptoms.
DLB is sensivity to antipsychotic drugs. We see also REM behavior disorder. Visual hallucinations and fluctuations in cognition, attention and allertness.
Mild Cognitive Impairment or MCI
MCI causes a slight but noticeable and measurable decline in cognitive abilities, including memory and thinking skills. Long-term studies suggest that 15-20 percent of the aged 65 and older may have MCI. There is a difference between normal aging cognitive decline and MCI. With all kind of rating scales it is not possible to see any difference.
Biomarkers for Alzheimer's disease can be really measured to indicate the presence or absense of the disease. For AD there is only one biomarker accepted amyloid beta. Preclinical b. amyloid as biomarker is difficult and very expensive to detect and it is only possible in hospitals. Digital biomarkers can be used outside the hospital POC ( in the waiting room or at home).
Blood glucose levels are a biomarker for diabetes and blood cholesterol for heart disease.
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These are the most commonly misdiagnosed conditions.
It is a degenerative disorder of the central nervous system with symptoms including tremors in hands, arms or legs, stiff muscles, and problems with balance or walking.
However, it is commonly mistaken for Alzheimer’s disease, stroke, stress, a traumatic head injury and essential tremor.
The condition causes an overactive thyroid gland, and is the most common cause of hyperthyroidism.
Symptoms include eyes bulging, anxiety, sweating, rapid pulse, unplanned weight loss or gain, and extreme tiredness.
Without treatment, it can prove life-threatening, however it is often mistaken for depression, ageing and under-exercising.
It is a chronic arthritis-like disorder characterised by widespread pain.
However, symptoms - anxiety, sensitivity to pain and incapacitating fatigue - can be confused with rheumatoid arthritis and chronic fatigue syndrome.
Normal pressure hydrocephalus
It is a build-up of cerebrospinal fluid in the brain that most commonly occurs after a stroke or ahead injury from a fall.
Symptoms of unsteady gait, progressive dementia and urinary problems, can be interpreted as Alzheimer’s disease or Parkinson’s disease.
The progressive autoimmune disease that attacks the central nervous system has symptoms including muscle spasms, lack of coordination, balance problems, blurred vision and cognitive impairment.
However, it is commonly mistaken for a viral infection, lupus, Alzheimer’s disease and bipolar disorder.
It is an autoimmune disorder marked by an inability to digest gluten, a protein in wheat, rye and barley.
Symptoms can include vomiting, abdominal pain and bloating, diarrhoea, weight loss, anaemia and leg cramps.
However it can be mistaken for irritable bowel syndrome, Crohn’s disease and cystic fibrosis
Chronic fatigue syndrome
The complex disorder has no known cause but symptoms include loss of memory or concentration, a sore throat, painful lymph nodes in neck or armpits, unexplained muscle or joint pain and extreme exhaustion.
It is often confused with sinus problems, hepatitis, fibromyalgia, lupus and rheumatoid arthritis.
It is a chronic inflammatory disease, with symptoms including fatigue, kidney, heart and lung damage, rash and joint pain.
However, it can be mistaken for chronic fatigue syndrome, fibromyalgia and rheumatoid arthritis.
This is where a tear develops in the aorta, the largest blood vessel branching from the heart, which causes the inner and middle layers to separate.
Symptoms can include sudden chest or upper back pain, loss of consciousness, shortness of breath, sweating and weak pulse in one arm.
However it can be misdiagnosed as heartburn, heart attack and stroke.