As we age the diversity and stability of our microbiota will decline. There is an associated increase in number, size and activation of microglia that can lead to an increased inflammatory..."INFLAMMAGING" ( von Bernhard et al 2015). Also there is a correlation between some bacteria and the amount of soluble amyloid (Harach et al 2015). By identifying disease associated bacterial population, scientists can explore ways to alter the microbiome and disease risk with diet and drugs.Microbes conforming to the Alzheimer's disease microbiome that induce immunosuppression, are pathogenic, are able to evade the innate and adaptive immune recognition, incite local inflammation and are incapable of allowing entry of activated peripheral blood myeloid cells in the brain. The periodontal microbiome does concur with the type of expected bacteria in Alzheimer's brains. bacteria populating the gut microbiota can secrete large amounts of amyloids and lipopolysaccharides, which might contribute to the modulation of signaling pathways and the production of proinflammatory cytokines associated with the pathogenesis of AD.
Extracts from organic tea leaves, sugar shall increase absorption , vegetable glycerin,sodium alginate (from seaweed)
The gut microbiota comprises a complex community of microorganism species that resides in our gastrointestinal ecosystem and whose alterations influence not only various gut disorders but also central nervous system disorders such as Alzheimer's disease (AD). . Studies in germ-free animals and in animals exposed to pathogenic microbial infections, antibiotics, probiotics, or fecal microbiota transplantation suggest a role for the gut microbiota in host cognition or AD-related pathogenesis. The increased permeability of the gut and blood-brain barrier induced by microbiota dysbiosis may mediate or affect AD pathogenesis and other neurodegenerative disorders, especially those associated with aging. Imbalances in the gut microbiota can induce inflammation that is associated with the pathogenesis of Alzheimer's disease.
Chronic periodontitis is a risk factor of Alzheimer's disease. There is a significant association. Polyphenols from some teas shall give an interaction with the gut microbiome and shall significantly decreased the biodiversity of the microbiol community in a dose-dependent manner. Alterations in the gut microbiome (gut-brain axis) may contribute to amyloid deposition and can influence cerebral amyloid deposition.
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